Bomb threat causes evacuation of Texas A&M

A bomb threat caused Texas A&M to order an evacuation of all students and faculty from its main campus on Friday.

The university said it issued a "Code Maroon" message?after a general threat to the campus in College Station, Texas, was received around 11:34 a.m. No details about the threat were released.

Classes were canceled for the rest of the day, the university statement said.

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The university asked students and faculty to proceed on foot and to not use vehicle, but traffic routes in and out of the campus were jammed, police said. About 50,000 students attend classes on the campus in College Station, about 100 miles northwest of Houston.

See more coverage on the evacuation at NBCDFW.com

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Source: http://usnews.nbcnews.com/_news/2012/10/19/14560696-bomb-threat-causes-evacuation-of-texas-am-university-traffic-jam?lite

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First-of-its-kind self-assembled nanoparticle for targeted and triggered thermo-chemotherapy

ScienceDaily (Oct. 18, 2012) ? Excitement around the potential for targeted nanoparticles (NPs) that can be controlled by stimulus outside of the body for cancer therapy has been growing over the past few years. More specifically, there has been considerable attention around near-infrared (NIR) light as an ideal method to stimulate nanoparticles from outside the body. NIR is minimally absorbed by skin and tissue, has the ability to penetrate deep tissue in a noninvasive way and the energy from NIR light can be converted to heat by gold nanomaterials for effective thermal ablation of diseased tissue.

In new research from Brigham and Women's Hospital (BWH), researchers describe the design and effectiveness of a first-of-its-kind, self assembled, multi-functional, NIR responsive gold nanorods that can deliver a chemotherapy drug specifically targeted to cancer cells and selectively release the drug in response to an external beam of light while creating heat for synergistic thermo-chemo mediated anti-tumor efficacy. The study is electronically published in Angewandte Chemie International Edition.

"The design of this gold nanorod and its self-assembly was inspired by nature and the ability of complimentary strands of DNA to hybridize on their own without imposing complicated chemical processes on them," explained Omid Farokhzad, MD, an anesthesiologist, director of the Laboratory of Nanomedicine and Biomaterials at BWH, and senior author of this study. "Each functionalized DNA strand individually, and the self assembled components as a system, play a distinct yet integrative role resulting in synergistic targeted and triggered thermo-chemotherapy capable of eradicating tumors in our pre-clinical models."

One DNA strand is attached to the gold nanorod and the complementary strand is attached to a stealth layer and a homing molecule that keeps the system under the radar of the immune system while targeting it directly to cancer cells. When the DNA strands come together, the targeted gold nanorod is formed and the double stranded DNA serves as the scaffold for binding the chemotherapy drug, doxorubicin, which can be released in response to NIR light that concurrently results in generation of heat by the gold nanorods.

"This new platform is composed of three distinct functional components and each plays a role in contributing to the triple punch of triggered thermotherapy, controlled doxorubicin release, and cancer cell targeting," explained Zeyu Xiao, PhD, a postdoctoral fellow at BWH and lead author of this study.

To demonstrate the robust capability of this nanorod system, Farokhzad and colleagues used a pre-clinical model to evaluate the in vivo anti-tumor efficacy in two different tumor models and four different groups with different drug regiments, each group varying in weight and tumor size. Researchers administrated an injection of the novel, self-assembled nanoparticle and then 10 minutes post-injection, the tumors were irradiated using NIR light that activated the nanoparticle using the gold nanorod and created heat. The results showed that this platform successfully delivered heat and anti-cancer drugs and synergistically eradicated tumors.

"Thermal ablation is already commonly used in cancer treatment," said Dr. Farokhzad. "What is extremely exciting about this platform is that we are able to selectively target cancer cells and then hit the tumor twice: first with a controlled release of a chemotherapy drug and then secondly with triggered induction of heat from the activation of the gold nanorod. And all this can be done noninvasively."

Researchers acknowledge that more research is necessary in other pre-clinical models before testing the safety and efficacy of this platform in human clinical trials.

This research was supported by the National Institutes of Health under grant number CA151884 and the David Koch-Prostate Cancer Foundation Program in Cancer Nanotherapeutics. O.C.F. has financial interest in BIND Biosciences, Selecta Biosciences, and Blend Therapeutics, biopharmaceutical companies that are developing therapeutic nanoparticles.

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Story Source:

The above story is reprinted from materials provided by Brigham and Women's Hospital.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Zeyu Xiao, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, Omid C. Farokhzad. DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy. Angewandte Chemie International Edition, 2012; DOI: 10.1002/anie.201204018

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/N8DJGF5MnUc/121018162209.htm

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Cauley, Dawson tied for lead at Sea Island

Bud Cauley reacts after missing a birdie putt on the 18th green during the first round of The McGladrey Classic PGA Tour golf tournament, Thursday, Oct. 18, 2012, in St. Simons Island, Ga. (AP Photo/Stephen Morton)

Bud Cauley reacts after missing a birdie putt on the 18th green during the first round of The McGladrey Classic PGA Tour golf tournament, Thursday, Oct. 18, 2012, in St. Simons Island, Ga. (AP Photo/Stephen Morton)

Bud Cauley tees off on the 17th hole during the first round of The McGladrey Classic PGA Tour golf tournament on Thursday, Oct. 18, 2012, in St. Simons Island, Ga. (AP Photo/Stephen Morton)

Marco Dawson prepares to putt on the fourth green during the first round of The McGladrey Classic PGA Tour golf tournament, Thursday, Oct. 18, 2012, in St. Simons Island, Ga. (AP Photo/Stephen Morton)

Zach Johnson watches his shot off the 12th tee during the first round of The McGladrey Classic PGA Tour golf tournament, Thursday, Oct. 18, 2012, in St. Simons Island, Ga. (AP Photo/Stephen Morton)

Greg Owens, of England, hits his drive off the ninth tee during the first round of The McGladrey Classic PGA Tour golf tournament Thursday, Oct. 18, 2012 in St. Simons Island, Ga. (AP Photo/Stephen Morton)

ST. SIMONS ISLAND, Ga. (AP) ? Bud Cauley has the same good vibes at Sea Island, even if the stakes are different this time.

The McGladrey Classic is where Cauley did well enough to secure his PGA Tour card, joining an elite list of players who went from college to a full tour card without going to Q-school. Now he's after his first win, and Cauley took a big step Thursday by overpowering the course for an 8-under 62.

It was his best score on the tour, and it gave him a share of the lead with Marco Dawson.

Winning is about all that's left for Cauley, the 22-year-old who left Alabama after his junior season. He already has made over $1.7 million this year, and has moved up to No. 55 in the world.

"Obviously, I've thought about winning every tournament I've teed up in this year," Cauley said. "It's been a long year, and although I've played a lot this year, I haven't won. It's still a goal of mine, but I'm not thinking about that while I'm out there, or putting any more pressure on myself this week. The season is kind of wining down. It would be great to win here."

Dawson is in a more desperate position.

The McGladrey Classic is the penultimate PGA Tour event on the schedule that counts toward the money list, and Dawson is at No. 216 with only $62,026 in 20 tournaments. The top 125 earn full cards for next year, so Dawson likely has to win to avoid a return to Q-school. His year has gone so badly that Dawson doesn't even look at the money list.

"I'm so far away from it that the only thing I can do is just try and play well," Dawson said. "And when I am playing well, just to keep it going instead of kind of messing it up like I have during the year."

Two guys on the bubble ? Boo Weekley (No. 121) and Rod Pampling (No. 124) joined Greg Owen at 64. Ryder Cup captain Davis Love III, the tournament host, was in a group at 65 that included Sea Island neighbor Zach Johnson, David Toms and Camilo Villegas, who is No. 152 on the money list.

Jim Furyk shot 66 in his first event since the Ryder Cup.

Dawson had a chance to mess up even a great day.

He twice had to take penalty strokes after errant tee shots on his last six holes and wound up losing only one shot. He took his lone bogey on the fourth hole, and then his tee shot on the par-5 seventh hit a tree and went into the water. Dawson took his drop, played 100 yards short of the green, hit wedge to 25 feet and holed the putt for par.

Cauley didn't have too many issues like that. He didn't have a par putt longer than 4 feet, and the slight kid from Jacksonville, Fla., pounded one tee shot after another, setting up wedges into many of the greens. He ran off four birdies in a five-hole stretch on the back nine that carried him to a 29.

"There were a couple of shorter holes where if you get in the fairway, you have wedges in your hand. And I really just hit good shots, drove the ball in the fairway and put wedges in my hand," he said. "Just hit good wedge shots and put the ball in the right spot on the green to leave myself pretty easy putts."

For so many other players, there is nothing easy about this week.

Weekley doesn't pay attention to details. Remember, this is the guy who once asked Paul Lawrie how he qualified for the British Open when it returned to Carnoustie ? where Lawrie made history with his wild, 10-shot comeback against Jean Van de Velde. Weekley, though, could tell you exactly where he is on the money list. He is aware that he has to play well in the last two weeks to make sure he has a full job next year, and he responded Thursday.

Trying to lighten the mood on the course, he talked endlessly with his caddie about fishing. And it helps to be playing a coastal course off the Atlanta, for Weekley has won twice at Hilton Head, just up the coast in South Carolina.

"It's been a long time coming," Weekley said. "I finally started making some putts, and I've been hitting the ball good, pretty good the last two weeks, and finally today the putts showed up, so hoping I carry it on this week."

Pampling can speak from experience. A year ago, he missed the cut in the final event at Disney and still wound up at No. 125 to keep his card. A year later, he's back in the same spot. For such an idyllic resort as Sea Island, there's an awful lot of stress inside the ropes.

"It hasn't been a lot of fun the last few years," Pampling said. "I've been playing good, but I haven't score. And it's all down to the putting. Nothing is going in."

He made plenty of putts on the back nine, where he shot 30. That was soothing.

The conditions never changed much during the day, and the course that usually is protected by wind was vulnerable. The lone defense was the greens, which are fast enough that even lag putts seem to run out 4 or 5 feet beyond the hole.

More than half of the 132-man field ? 86 players ? broke par.

Former U.S. Amateur champion Danny Lee was another reminder that this week isn't peaceful for everyone. Lee is No. 167, with time running out, so he was pleased with his start ? in the round and in the tournament. He already was 5 under through seven holes with an eagle at the par-5 seventh, though he didn't make up much ground from there. Even so, the 65 follows a strong week in California when he tied for 16th.

"It feels like I got fire on my (behind) right now," Lee said. "Just want to maintain this because I want to play on the PGA Tour for a long, long time. Top 150 you still get into a few events, so that's what I'm actually looking at right now. But after this round, it might turn around."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-10-18-GLF-McGladrey-Classic/id-265009321de042609fdd8976442274cc

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How To Pick Winning Lotto Numbers - Discover How To Win The ...

Would you like to know the secret to the way to choose winning lotto numbers? Do you purchase lottery tickets every day? Do not you wish you could just win already? Should you answered yes then you definitely should keep reading this short article. There are actually lots of effortless points that you could do that will give you a greater possibility of winning. All you need to complete is follow a few very simple measures.

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Source: http://www.articlesnatch.com/Article/How-To-Pick-Winning-Lotto-Numbers---Discover-How-To-Win-The-Lottery-Now-/4218909

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Ex-presidential nominee George McGovern no longer responsive: family

(Reuters) - Former Democratic Senator George McGovern, remembered for a devastating defeat by Richard Nixon in the 1972 presidential election and his efforts to fight world hunger, was near death on Wednesday at a South Dakota hospice center, his family said.

McGovern, 90, was admitted to a hospice suffering from a combination of medical conditions due to age that have worsened in recent months, his family said in a statement.

"The senator is no longer responsive," the statement said. "He is surrounded by his loving family and close friends."

McGovern, who served in the Senate for South Dakota from 1963 to 1981, challenged Nixon in 1972 on a platform opposing the war in Vietnam. He suffered one of the most lopsided defeats in U.S. history, taking only 37.5 percent of the vote and carrying only Massachusetts and the District of Columbia.

Later as Nixon's presidency unraveled in the Watergate scandal, bumper stickers saying "Don't blame me, I'm from Massachusetts" and buttons saying "Don't blame me, I voted for McGovern" began to appear.

But McGovern's legacy stretches well beyond his terms in Congress and presidential bids, to social issues including world hunger and AIDS, said Donald Simmons, director of the McGovern Center for Leadership and Public Service at Dakota Wesleyan University in Mitchell, South Dakota.

"Outside of the U.S., he is known for his real humanitarian efforts and I think that will be one of his greatest long term legacies," Simmons said Wednesday in a telephone interview.

The son of a Methodist minister, McGovern flew combat missions over Europe as a B-24 bomber pilot during World War Two, earning the Distinguished Flying Cross.

He was elected to the U.S. House of Representatives in 1956, and re-elected two years later. After McGovern lost a U.S. Senate election in 1960, President John F. Kennedy named him the first director of the Food for Peace Program.

He also ran for president in 1968 after the assassination of front-runner Robert F. Kennedy and a short-lived bid for the Democratic presidential nomination in 1984.

McGovern said he had moved on from his 1972 defeat but 12 years later another defeated Democratic presidential candidate, Walter Mondale, asked him how long it took to get over losing in a landslide. "I'll let you know when I get there," McGovern replied.

As a soft-spoken academic from South Dakota - he was a history and political science professor at Dakota Wesleyan - and a decorated pilot, McGovern did not fit the model of many of the leaders of the anti-war movement of the 1960s and 1970s.

McGovern became a campaigner for world food issues in his post-politics life, often joining former Senator Bob Dole in his work. He wrote several books, including an autobiography, the story of his daughter's struggle with alcoholism, and "What it Means to Be a Democrat" released last year.

He also continued to make television appearances and write editorials and commentaries, Simmons said. McGovern often lamented what he saw as a lack of a true public debate on policy issues from members of both parties, he said.

McGovern had been hospitalized several times in the past year after complaining of fatigue after a book tour, a fall before a scheduled television appearance and dizzy spells.

In 2000, President Bill Clinton awarded him the Presidential Medal of Freedom, America's highest civilian honor.

On Wednesday, McGovern's family encouraged people to donate to Feeding South Dakota (www.feedingsouthdakota.org) if they planned to offer remembrances of the senator.

McGovern and wife Eleanor, who died in 2007, had five children.

(Reporting by David Bailey; Editing by Cynthia Johnston and Bill Trott)

Source: http://news.yahoo.com/ex-senator-presidential-nominee-mcgovern-no-longer-responsive-191525402.html

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Internet Marketing For Small Business Owners - Work At Home

The only people you work online income. Internet is and anything else. Writing for one idea make the mistake you can apply as much as 20 application is free each day.

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Source: http://workathomeandmakemoney.org/internet-marketing-for-small-business-owners/

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XCOM Isn't Dumbed Down For Consoles, It's Smartened Up

Every time a classic PC game is moved over to consoles, we tend to hear the same worries: It's been dumbed down; it's oversimplifed, rendered toothless and worthless. When XCOM: Enemy Unknown was released on both PC and consoles, it would have been easy to jump to the same conclusions.

And in many ways, XCOM has indeed been greatly simplified when compared to its PC predecessor. You'll only have one base, only a few mission variants, and most crucially, action points have been removed. But the end result isn't a dumber, casual-friendly version of the X-Com we all know and love. From top to bottom, it's a smarter, more economical and gripping game. Firaxis somehow managed to keep the essence of XCOM while still making it simple enough to be managed with a controller.

When I first started up the preview code of Enemy Unknown, I just thought of it as a PC game. I didn't really think through how a controller would work, or think much about the console versions at all. However, I'd moved my PC over to the TV to play that game's super good PC version on the big screen. I wanted to play XCOM, so I figured I'd try it with a controller. I was amazed.

This game works just fine with a controller, which makes me happy to recommend it to anyone, regardless of platform. (This is good, because I like recommending XCOM to everyone I possibly can.) In fact, some aspects of the game work better with a controller, particularly the finicky grenade-throwing and level-switching.

The key is that the most complicated machinations take place in your brain and aren't represented by on-screen nomenclature. In what order should I move my team? Can I damage this enemy enough that an un-covered attack will kill it? Shall I heal first, then move, or move, then heal? When should my team reload?

In this smart, spot-on article at Gamespy, Rob Zacny breaks down the way XCOM's strategy works, and how, in his words, "Granularity isn't greatness." Zacny points out that as much as he likes the moves granular systems let him pull in games like X-Com: UFO Defense and Jagged Alliance 2, there's actually a point of diminishing returns for granularity. In reality, he tends to think in broader strokes like the ones represented in Enemy Unknown.

XCOM:EU may be simpler, but the problems I'm using its tools to solve are as thorny as those I've encountered in more hardcore wargames. You can move and take an action, or you can move far and take no action. This is pretty much the same choice I face 95% of the time in a wargame. The difference is that XCOM:EU expresses it simply as a "run, or take a smaller move and shoot." A more "serious" game expresses the same dilemma as "use 13 points for movement and crouch for 1, or use 6 points for movement and take a shot for 8." XCOM:EU never wants you to spend your time worrying about those numbers and counting spaces; it just wants you to move from tradeoff to tradeoff. That might give you less freedom and fine control over your troops, but it also means that XCOM:EU moves along as a great pace, as opposed to the occasional tedium that could mire Jagged Alliance and old X-COM.

I'm right there with Zacny?I'm amazed at how complex and smart XCOM is, whether I've got a mouse and keyboard in my hand, or a controller.

XCOM: Enemy Unknown and the Alleged "Dumbing Down" of Strategy Games [GameSpy]

Source: http://kotaku.com/5952294/xcom-isnt-dumbed-down-for-consoles-its-smartened-up

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